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Understanding Joint Injections: Cortisone, Viscosupplementation, and PRP

joint injections

By Brian Reiter, MD
Fellowship-Trained in Sports Medicine, Atlantis Orthopaedics

Joint pain is common, and injections can provide relief while avoiding surgery. With several options available, it can be confusing to know which treatment is right for you. Here’s a breakdown of three commonly used injection therapies:

Cortisone Injections

Purpose: Rapid relief of pain and swelling from acute arthritis or flare-ups
Benefits: Quick symptom relief
Considerations: Repeated use may weaken tendons or cartilage

Viscosupplementation (Hyaluronic Acid Injections)

Purpose: Supplements joint fluid to improve mobility and reduce pain
Benefits: Sustained relief for several months, especially in osteoarthritis
Considerations: Effects take longer than cortisone; often used in older patients

Platelet-Rich Plasma (PRP)

Purpose: Uses your own platelets to promote tissue repair and reduce inflammation
Benefits: Particularly effective for chronic pain and early-stage arthritis
Considerations: Insurance coverage may be limited; results vary by patient age and joint condition

Comparative Effectiveness: PRP vs. Viscosupplementation

Recent meta-analyses show PRP often provides:

  • Higher rates of successful outcomes
  • Better pain relief
  • Greater functional improvement

Duration of effect: PRP may last up to 12 months or more, versus 6–12 months for hyaluronic acid (HA).

PRP vs. Viscosupplementation: At a Glance

Feature

PRP Injections

Viscosupplementation (HA)

Mechanism

Promotes healing via platelets

Supplements joint fluid

Onset of Relief

Several weeks

Several weeks

Duration

Up to 12+ months

6–12 months

Efficacy

Higher success rates

Effective but lower rates

Safety

Generally safe

Generally safe

Insurance

Often limited/out-of-pocket

Often covered

Cost

Higher

Lower

Choosing the Right Injection
  • Age: Younger patients → PRP/HA; Older patients → Cortisone
  • Acuity of pain: Rapid/severe → Cortisone; Chronic/low-grade → PRP/HA
  • Insurance coverage: Cortisone widely covered, PRP often out-of-pocket
  • Patient goals: Shared decision-making is essential

Each injection has a role. A discussion with your orthopaedic specialist can determine the safest, most effective option for you.

About Dr. Brian Reiter

Brian Reiter, MD, is fellowship-trained in sports medicine and specializes in minimally invasive orthopaedic techniques. He is part of Atlantis Orthopaedics and is core faculty in the only Orthopaedic residency program in Palm Beach County.

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If you’re experiencing joint pain or considering an injection treatment, schedule an appointment with Dr. Brian Reiter at Atlantis Orthopaedics today.

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